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‘Our institute has worked to develop this technology to answer a fundamental question about cancer. These results show that the interactions of a DNA sequence of a genome scale can explain some inconsistencies in previous studies. This work will pave the way for the development of highly specific anti-hormone treatment of breast cancer, ‘said Edison Liu, MD, Executive Director of GIS, one of the research institutes sponsored by the Agency of Singapore for Science, Technology and Research .Map interaction Chia-PET methodology and ER-human chromatin is the starting point for an entirely new field for scientists to study how the human genome is folded in order to communicate the codes in regulating gene expression. Crucial to elucidate the mechanisms of control of the genome during cell differentiation, Chia-PET and the map of the interactions of chromatin may lead to a better understanding and control of diseases. This method is based on gene sequencing method known as Revolutionary associated end-DITAG sequencing, which was pioneered in 2005 by scientists of the GIS, led by the leader of the main group, Yijun Ruan, Ph., And Chia- Lin Wei, Phil. D.
The authors conclude: ‘At the moment, we do not understand what causes IPF-CS, because the incidence is increasing or the best way to treat individuals with this spectrum of illness.
‘The subsequent discovery of chromatin interactions between specific genes and specific enhancer sites generated much interest in the search for interactions of chromatin throughout the genome. Our study is the first to be able to deal with this’ holy grail ‘of genomics’ he said.
D., lead author of research and a member of a team of scientists led by Yijun Ruan GIS, Ph.D., senior group leader and deputy director of genomic technologies, and Senior Research Scientist Edwin Cheung, Ph.D.
Chia-use PET technology, GIS scientists have met the challenge and confirmed the presence of the entire genome of long-range chromatin interactions.
This work has been recognized and supported by a grant from the National Institutes of Health public research consortium known as ENCODE .
Since the human genome has been found to be organized in three dimensions rather than a linear two-dimensional, have challenged scientists to find an effective method to study the regulation of gene activity that took into account the complexity its 3D structure.
‘Thinking about how this could happen, many scientists have hypothesized that interactions of chromatin – 3-dimensional rings of DNA – may be what allows these regions to speak at a distance of genes,’ Dr. Fullwood said.